The Second Life of Mirielle West by Amanda Skenandore follows Mirielle West, a glamorous Hollywood socialite in the 1920s, who is diagnosed with leprosy and sent to a quarantined facility in Carville, Louisiana. Struggling to adapt, she initially resists but eventually finds purpose and community among the other patients while navigating personal losses, evolving relationships, and a quest for a cure. Topics include the social stigma of illness, familial rejection, and the repercussions of substance misuse.

The Second Life of Mirielle West by Amanda Skenandore is praised for its engaging depiction of 1920s leprosy treatment and immersive historical detail. Readers commend the character development and emotional depth. However, some reviews note a predictable plot and slow pacing. This richly atmospheric novel explores resilience and transformation, though it may not surprise seasoned historical fiction fans.

Fans of historical fiction with strong female protagonists will relish Amanda Skenandore's The Second Life of Mirielle West. Perfect for readers who enjoyed The Paris Wife by Paula McLain or The Nightingale by Kristin Hannah, this novel immerses you in the poignant journey of its resilient, complex heroine amidst early 20th-century leper colony life.

Emotional / Melancholic / Contemplative / Mysterious / Inspirational

**Mirielle West**  
The protagonist who, accustomed to a high-society life as the wife of a famous actor, is sent to Carville where she navigates a significant personal transformation. Known for her beauty and fashionable style, she initially struggles with the implications of her diagnosis.

**Sister Verena**  
The stern head nurse at Carville who serves as a mentor to Mirielle, helping her adjust to her new life. Her unwavering commitment to her work makes her a role model for the patients at the colony.

**Frank Garrett**  
A cheerful and upbeat resident at Carville who introduces Mirielle to the community. Known for his leadership of the What Cheer Club, he provides support and joy to the patients.

**Irene**  
An outspoken and confident patient at Carville who works as an orderly in house 18. Despite her strong-willed nature, she also serves as a reality check for Mirielle, encouraging her to face certain truths about life in the colony.

**Jean**  
A nine-year-old prankster at Carville who struggles with her family's abandonment. Her interactions with Mirielle highlight themes of nurturing and growth.

**Hector**  
A quiet and compassionate patient who travels with Mirielle to Carville, forming a bond with her through their shared experiences. Despite facing prejudice due to his heritage, he remains optimistic and dedicated to supporting his family.

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Chapters 28-41

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Chapters 42-54

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Chapter 55-Epilogue

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